The Gilmore Lab focuses on developing new ways to prevent and treat antibiotic resistant infections. We believe the core genome of enterococci and staphylococci evolved to enable stable commensal relationship with the host. However, this stability is undermined by environmental changes, changes in the host, or the introduction into the microbe of new traits on mobile elements. We identify traits on mobile elements that destabilize the host commensal relationship, determine their origin, and define how they undermine the balance. These studies employ epidemiology, molecular genetics and genomics, cell biology and pathogenesis in animal models.
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